原著論文(共同研究の論文を含む)

<2017年>

1) Tanisawa K, Hirose N, Arai Y, Shimokata H, Yamada Y, Kawai H, Kojima M, Obuchi S, Hirano H, Suzuki H, Fujiwara Y, Taniguchi Y, Shinkai S, Ihara K, Sugaya M, Higuchi M, Arai T, Mori S, Sawabe M, Sato N, Muramatsu M, Tanaka M. Inverse association between height-increasing alleles and extreme longevity in Japanese women. J Gerontol A Biol Sci Med Sci 2017 (in press)
(PMID: 28958036; DOI: 10.1093/gerona/glx155)


2)  Gondo Y, Hirose N, Yasumoto S, Arai Y, Saito Y. Age verification of the longest lived man in the world. Exp Gerontol 2017 (in press)
(PMID: 28847724; DOI: 10.1016/j.exger.2017.08.030)


3)  Hirata T, Arai Y, Takayama M, Abe Y, Okuma K, Takebayashi T. Carotid plaque score and risk of cardiovascular mortality in the oldest old: Results from the TOOTH study. J Atheroscler Thromb 2017 (in press)
(PMID: 28179606; DOI: 10.5551/jat.37911)


4)  Nakagawa T, Cho J, Gondo Y, Martin P, Johnson MA, Poon LW, Hirose N. Subjective well-being in centenarians: a comparison of Japan and the United States. Aging Ment Health 2017 (in press)
(PMID: 28682113; DOI: 10.1080/13607863.2017.1348477)


5) Okubo H, Inagaki H, Gondo Y, Kamide K, Ikebe K, Masui Y, Arai Y, Ishizaki T, Sasaki S, Nakagawa T, Kabayama M, Sugimoto K, Rakugi H, Maeda Y; SONIC study group. Association between dietary patterns and cognitive function among 70-year-old Japanese elderly: a cross-sectional analysis of the SONIC study. Nutr J 2017; 16: 56.
(PMID: 28893250; DOI: 10.1186/s12937-017-0273-2)


6) Sato R, Arai Y, Abe Y, Takayama M, Urushihara H. The drug burden of anticholinergics and sedatives and influence on outcomes in the community-living oldest old: The Tokyo Oldest Old survey on Total Health (TOOTH) survey. Nihon Ronen Igakkai Zasshi 2017; 54: 403-416 [Japanese].
(PMID: 28855465; DOI: 10.3143/geriatrics.54.403)


7) Tada S, Ikebe K, Kamide K, Gondo Y, Inomata C, Takeshita H, Matsuda KI, Kitamura M, Murakami S, Kabayama M, Oguro R, Nakama C, Kawai T, Yamamoto K, Sugimoto K, Shintani A, Ishihara T, Arai Y, Masui Y, Takahashi R, Rakugi H, Maeda Y. Relationship between atherosclerosis and occlusal support of natural teeth with mediating effect of atheroprotective nutrients: From the SONIC study. PLoS One 2017; 12: e0182563.
(PMID: 28817589; DOI: 10.1371/journal.pone.0182563)


8) Arai Y, Sasaki T, Hirose N. Demographic, phenotypic, and genetic characteristics of centenarians in Okinawa and Honshu, Japan: Part 2 Honshu, Japan. Mech Ageing Dev 2017; 165: 80-85.
(PMID: 28214534; DOI: 10.1016/j.mad.2017.02.005)


9) Iinuma T, Hirata T, Arai Y, Takayama M, Abe Y, Fukumoto M, Fukui Y, Gionhaku N. Perceived swallowing problems and mortality risk in very elderly people ≥85 years old: Results of the Tokyo Oldest Old Survey on Total Health study. Gerodontology 2017; 34: 313-319.
(PMID: 28349594; DOI: 10.1111/ger.12265)


10) Arai Y. The prevalence and risk factors of dementia in centenarians. Brain Nerve 2017; 69(7): 771-780 [Japanese].
(PMID: 28739991; DOI: 10.11477/mf.1416200819)


11) Arai Y. Aging and homeostasis. Biomedical peculiarities of semi-supercentenarians. Clin Calcium 2017; 27(7): 969-974 [Japanese].
(PMID: 28649103; DOI: CliCa1707969974)


12) Iinuma T, Arai Y, Takayama M, Takayama M, Abe Y, Osawa Y, Fukumoto M, Fukui Y, Shioda Y, Hirose N, Komiyama K, Gionhaku N. Satisfaction with dietary life affects oral health-related quality of life and subjective well-being in very elderly people. J Oral Sci 2017; 59(2): 207-213.
(PMID: 28637980; DOI: 10.2334/josnusd.16-0414)


13) Osawa Y, Arai Y, Takayama M, Hirata T, Kawasaki M, Abe Y, Iinuma T, Sasaki S, Hirose N. Identification of dietary patterns and their relationships with general and oral health in the very old. Asia Pac J Clin Nutr 2017; 26(2): 262-270.
(PMID: 28244704; DOI: 10.6133/apjcn.022016.02)


14) Ryuno H, Kamide K, Gondo Y, Kabayama M, Oguro R, Nakama C, Yokoyama S, Nagasawa M, Maeda-Hirao S, Imaizumi Y, Takeya M, Yamamoto H, Takeda M, Takami Y, Itoh N, Takeya Y, Yamamoto K, Sugimoto K, Nakagawa T, Yasumoto S, Ikebe K, Inagaki H, Masui Y, Takayama M, Arai Y, Ishizaki T, Takahashi R, Rakugi H. Longitudinal association of hypertension and diabetes mellitus with cognitive functioning in a general 70-year-old population: the SONIC study. Hypertens Res 2017; 40(7): 665-670.
(PMID: 28230198; DOI: 10.1038/hr.2017.15)


15) Oguma Y, Osawa Y, Takayama M, Abe Y, Tanaka S, Lee IM, Arai Y. Validation of questionnaire-assessed physical activity in comparison with objective measures using accelerometers and physical performance measures among community-dwelling adults aged ≥85 years in Tokyo, Japan. J Phys Act Health 2017; 14(4): 245-252.
(PMID: 27918699; DOI: 10.1123/jpah.2016-0208)


16) Osawa Y, Arai Y, Oguma Y, Hirata T, Abe Y, Azuma K, Takayama M, Hirose N. Relationships between anterior thigh muscle echo intensity and physical activity and functional mobility in a very old population. J Aging Phys Act 2017; 25(2): 189-195.
(PMID: 27623344; DOI: 10.1123/japa.2015-0203)


17) Tanisawa K, Arai Y, Hirose N, Shimokata H, Yamada Y, Kawai H, Kojima S, Obuchi S, Hirano H, Yoshida H, Suzuki H, Fujiwara Y, Ihara K, Sugaya M, Arai T, Mori S, Sawabe M, Sato N, Muramatsu M, Higuchi M, Liu YW, Kong QP, Tanaka M. Exome-wide association study identifies CLEC3B missense variant p.S106G as being associated with extreme longevity in East Asian populations. J Gerontol A Biol Sci Med Sci 2017; 72(3): 309-318.
(PMID: 27154906; DOI: 10.1093/gerona/glw074)


18) Ogawa T, Uota M, Ikebe K, Arai Y, Kamide K, Gondo Y, Masui Y, Ishizaki T, Inomata C, Takeshita H, Mihara Y, Hatta K, Maeda Y. Longitudinal study of factors affecting taste sense decline in old-old individuals. J Oral Rehabil 2017; 44(1): 22-29.
(PMID: 27748531; DOI: 10.1111/joor.12454)


<2016年>

1) Santos-Lozano A, Pareja-Galeano H, Fuku N, Hirose N, Emanuele E, Lucia A, Sanchis-Gomar F. Implications of obesity in exceptional longevity. Ann Transl Med 2016; 4: 416.
(PMID: 27867968)


2) Fuku N, Alis R, Yvert T, Zempo H, Naito H, Abe Y, Arai Y, Murakami H,Miyachi M, Pareja-Galeano H, Emanuele E, Hirose N, Lucia A. Muscle-related polymorphisms (MSTN rs1805086 and ACTN3 rs1815739) are not associated with exceptional longevity in Japanese centenarians. PLoS One 2016; 11: e0166605.
(PMID: 27861536; DOI: 10.1371/journal.pone.0166605)


3) Fuku N, Díaz-Peña R, Arai Y, Abe Y, Pareja-Galeano H, Sanchis-Gomar F, Santos-Lozano A, Zempo H, Naito H, Murakami H, Miyachi M, Venturini L, Ricevuti G, Hirose N, Emanuele E, Lucia A. Rs2802292 polymorphism in the FOXO3A gene and exceptional longevity in two ethnically distinct cohorts. Maturitas 2016; 92: 110-114.
(PMID: 27621247; DOI: 10.1016/j.maturitas.2016.07.016)


4) Uota M, Ogawa T, Ikebe K, Arai Y, Kamide K, Gondo Y, Masui Y, Ishizaki T, Inomata C, Takeshita H, Mihara Y, Maeda Y. Factors related to taste sensitivity in elderly: cross-sectional findings from SONIC study. J Oral Rehabil 2016; 43(12): 943-952.
(PMID: 27627583; DOI: 10.1111/joor.12442)


5) Takao M, Hirose N, Arai Y, Mihara B, Mimura M. Neuropathology of supercentenarians – four autopsy case studies. Acta Neuropathol Commun 2016; 4(1): 97.
(PMID: 27590044; DOI: 10.1186/s40478-016-0368-6)


6) Iinuma T, Arai Y, Takayama M, Abe Y, Ito T, Kondo Y, Hirose N, Gionhaku N. Association between maximum occlusal force and 3-year all-cause mortality in community-dwelling elderly people. BMC Oral Health 2016; 16(1): 82.
(PMID: 27586200; DOI: 10.1186/s12903-016-0283-z)


7) Ishioka YL, Gondo Y, Fuku N, Inagaki H, Masui Y, Takayama M, Abe Y, Arai Y, Hirose N. Effects of the APOE ε4 allele and education on cognitive function in Japanese centenarians. Age (Dordr) 2016; 38(5-6): 495-503.
(PMID: 27558117; DOI: 10.1007/s11357-016-9944-8)


8) Brodaty H, Woolf C, Andersen S, Barzilai N, Brayne C, Cheung KS, Corrada MM, Crawford JD, Daly C, Gondo Y, Hagberg B, Hirose N, Holstege H, Kawas C, Kaye J, Kochan NA, Lau BH, Lucca U, Marcon G, Martin P, Poon LW, Richmond R, Robine JM, Skoog I, Slavin MJ, Szewieczek J, Tettamanti M, Vina J, Perls T, Sachdev PS. ICC-dementia (International Centenarian Consortium-dementia): an international consortium to determine the prevalence and incidence of dementia in centenarians across diverse ethnoracial and sociocultural groups. BMC Neurol 2016; 16: 52.
(PMID: 27098177; DOI: 10.1186/s12883-016-0569-4)


9) Ryuno H, Kamide K, Gondo Y, Nakama C, Oguro R, Kabayama M, Kawai T, Kusunoki H, Yokoyama S, Imaizumi Y, Takeya M, Yamamoto H, Takeda M, Takami Y, Itoh N, Yamamoto K, Takeya Y, Sugimoto K, Nakagawa T, Ikebe K, Inagaki H, Masui Y, Ishizaki T, Takayama M, Arai Y, Takahashi R, Rakugi H. Differences in the association between high blood pressure and cognitive functioning among the general Japanese population aged 70 and 80 years: The SONIC Study. Hypertens Res 2016; 39(7): 557-563. (PMID: 27009579; DOI: 10.1038/hr.2016.25)


10) Kawasaki M, Arai Y, Takayama M, Hirata T, Takayama M, Abe Y, Niimura H, Mimura M, Takebayashi T, Hirose N. Carotid atherosclerosis, cytomegalovirus infection, and cognitive decline in the very old: a community-based prospective cohort study. Age (Dordr) 2016; 38(2): 29.
(PMID: 26886582; DOI: 10.1007/s11357-016-9890-5)


11) Morris BJ, Chen R, Donlon TA, Evans DS, Tranah GJ, Parimi N, Ehret GB, Newton-Cheh C, Seto T, Willcox DC, Masaki KH, Kamide K, Ryuno H, Oguro R, Nakama C, Kabayama M, Yamamoto K, Sugimoto K, Ikebe K, Masui Y, Arai Y, Ishizaki T, Gondo Y, Rakugi H, Willcox BJ. Association analysis of FOXO3 longevity variants with blood pressure and essential hypertension. Am J Hypertens 2016; 29(11): 1292-1300.
(PMID: 26476085; DOI: 10.1093/ajh/hpv171)


12) Yoshinaka M, Ikebe K, Uota M, Ogawa T, Okada T, Inomata C, Takeshita H, Mihara Y, Gondo Y, Masui Y, Kamide K, Arai Y, Takahashi R, Maeda Y. Age and sex differences in the taste sensitivity of young adult, young-old and old-old Japanese. Geriatr Gerontol Int 2016; 16(12): 1281-1288.
(PMID: 26493051; DOI: 10.1111/ggi.12638)

<2015年>

1) Arai Y, Martin-Ruiz CM, Takayama M, Abe Y, Takebayashi T, Koyasu S, Suematsu M, Hirose N, von Zglinicki T. Inflammation, but not telomere length, predicts successful ageing at extreme old age: a longitudinal study of semi-supercentenarians. EBioMedicine 2015; 2(10): 1549-1558.
(PMID: 26629551; DOI: 10.1016/j.ebiom.2015.07.029)


2) Iinuma T, Arai Y, Abe Y, Takayama M, Fukumoto M, Fukui Y, Iwase T, Takebayashi T, Hirose N, Gionhaku N, Komiyama K. Denture wearing during sleep doubles the risk of pneumonia in the very elderly. J Dent Res 2015; 94(3 Suppl): 28S-36S.
(PMID: 25294364; DOI: 10.1177/0022034514552493)


3) Miura Y, Hashii N, Tsumoto H, Takakura D, Ohta Y, Abe Y, Arai Y, Kawasaki N, Hirose N, Endo T; SONIC (Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians). Change in N-glycosylation of plasma proteins in Japanese semisupercentenarians. PLoS One 2015; 10(11): e0142645.
(PMID: 26559536; DOI: 10.1371/journal.pone.0142645)


4) Fuku N, He ZH, Sanchis-Gomar F, Pareja-Galeano H, Tian Y, Arai Y, Abe Y, Murakami H, Miyachi M, Zempo H, Naito H, Yvert T, Verde Z, Venturini L, Fiuza-Luces C, Santos-Lozano A, Rodriguez-Romo G, Ricevuti G, Hirose N, Emanuele E, Garatachea N, Lucia A. Exceptional longevity and muscle and fitness related genotypes: a functional in vitro analysis and case-control association replication study with SNPs THRH rs7832552, IL6 rs1800795, and ACSL1 rs6552828. Front Aging Neurosci 2015; 7: 59.
(PMID: 25999849; DOI: 10.3389/fnagi.2015.00059)


5) Takeshita H, Ikebe K, Kagawa R, Okada T, Gondo Y, Nakagawa T, Ishioka Y, Inomata C, Tada S, Matsuda K, Kurushima Y, Enoki K, Kamide K, Masui Y, Takahashi R, Arai Y, Maeda Y. Association of personality traits with oral health-related quality of life independently of objective oral health status: a study of community-dwelling elderly Japanese. J Dent 2015; 43(3):342-349.
(PMID: 25542999; DOI: 10.1016/j.jdent.2014.12.011)


6) Fuku N, Pareja-Galeano H, Zempo H, Alis R, Arai Y, Lucia A, Hirose N. The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity? Aging Cell 2015; 14(6): 921-923.
(PMID: 26289118; DOI: 10.1111/acel.12389)


7) Okada T, Ikebe K, Kagawa R, Inomata C, Takeshita H, Gondo Y, Ishioka Y, Okubo H, Kamide K, Masui Y, Takahashi R, Arai Y, Thomson WM, Maeda Y. Lower protein intake mediates association between lower occlusal force and slower walking speed: from the Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians Study. J Am Geriatr Soc 2015; 63(11): 2382-2387.
(PMID: 26503826; DOI: 10.1111/jgs.13784)


8) Arai Y, Takayama M, Inagaki H, Gondo Y, Masui Y, Hirose N. Centenarian Studies: An Interdisciplinary Research on Healthy Longevity. In Aging Mechanism: Longevity, metabolism, and brain aging. Ed Mori N & Mook-Jung I. Springer, German, 2015.


9) Ishioka Y, Gondo Y, Masui Y, Nakagawa T, Tabuchi M, Ogawa M, Kamide K, Ikebe K, Arai Y, Ishizaki T, Takahashi R. Occupational complexity and late-life memory and reasoning abilities. Shinrigaku Kenkyu 2015; 86(3): 219-229 [Japanese].
(PMID: 26402953)


10) Congrains A, Kamide K, Hirose N, Arai Y, Oguro R, Nakama C, Imaizumi Y, Kawai T, Kusunoki H, Yamamoto H, Onishi-Takeya M, Takeya Y, Yamamoto K, Sugimoto K, Akasaka H, Saitoh S, Miura T, Awata N, Kato N, Katsuya T, Ikebe K, Gondo Y, Rakugi H. Disease-associated polymorphisms in 9p21 are not associated with extreme longevity. Geriatr Gerontol Int 2015; 15(6): 797-803.
(PMID: 25257646; DOI: 10.1111/ggi.12346)

<2014年>

1) Arai Y, Inagaki H, Takayama M, Abe Y, Saito Y, Takebayashi T, Gondo Y, Hirose N. Physical independence and mortality at the extreme limit of lifespan: Supercentenarians study in Japan. J Gerontol A Bio Sci Med Sci 2014; 69(4): 486-494.
(PMID: 24225329; DOI: 10.1093/gerona/glt146)


2) Sanchis-Gomar F, Garatachea N, He ZH, Pareja-Galeano H, Fuku N, Tian Y, Arai Y, Abe Y, Murakami H, Miyachi M, Yvert T, Santiago C, Venturini L, Fiuza-Luces C, Santos-Lozano A, Rodríguez-Romo G, Ricevuti G, Hirose N, Emanuele E, Lucia A. FNDC5 (irisin) gene and exceptional longevity: a functional replication study with rs16835198 and rs726344 SNPs. Age (Dordr) 2014; 36(6): 9733.
(PMID: 25427998; DOI: 10.1007/s11357-014-9733-1)


3) Horio E, Kadomatsu T, Miyata T, Arai Y, Hosokawa K, Doi Y, Ninomiya T, Horiguchi Y, Endo M, Tabata M, Tazume H, Tian Z, Takahashi O, Terada K, Takeya M, Hao H, Hirose N, Minami T, Suda T, Kiyohara Y, Ogawa H, Kaikita K, Oike Y. The role of endothelial cell-derived angptl2 in vascular inflammation leading to endothelial dysfunction and atherosclerosis progression. Arterioscler Thromb Vasc Biol 2014; 34(4): 790-800.
(PMID: 24526691; DOI: 10.1161/ATVBAHA.113.303116)


4) Garatachea N, Emanuele E, Calero M, Fuku N, Arai Y, Abe Y, Murakami H, Miyachi M, Yvert T, Verde Z, Zea MA, Venturini L, Santiago C, Santos-Lozano A, Rodríguez G, Ricevuti G, Hirose N, Rábano A, Lucia A. ApoE gene and exceptional longevity: Insights from three independent cohorts. Exp Gerontol 2014; 53: 16-23.
(PMID: 24534555; DOI: 10.1016/j.exger.2014.02.004)


5) Garatachea N, Fuku N, He ZH, Tian Y, Arai Y, Abe Y, Murakami H, Miyachi M, Yvert T, Venturini L, Santiago C, Santos-Lozano A, Rodríguez G, Ricevuti G, Pareja-Galeano H, Sanchis-Gomar F, Emanuele E, Hirose N, Lucia A. PTK2 rs7460 and rs7843014 polymorphisms and exceptional longevity: a functional replication study. Rejuvenation Res 2014; 17(5): 430-438.
(PMID: 24930376; DOI: 10.1089/rej.2014.1570)


6) Okada T, Ikebe K, Inomata C, Takeshita H, Uota M, Mihara Y, Matsuda K, Kitamura M, Murakami S, Gondo Y, Kamide K, Masui Y, Takahashi R, Arai Y, Maeda Y. Association of periodontal status with occlusal force and food acceptability in 70-year-old adults: from SONIC Study. J Oral Rehabil 2014; 41(12): 912-919.
(PMID: 25056986; DOI: 10.1111/joor.12214)


7) Inomata C, Ikebe K, Kagawa R, Okubo H, Sasaki S, Okada T, Takeshita H, Tada S, Matsuda K, Kurushima Y, Kitamura M, Murakami S, Gondo Y, Kamide K, Masui Y, Takahashi R, Arai Y, Maeda Y. Significance of occlusal force for dietary fibre and vitamin intakes in independently living 70-year-old Japanese: from SONIC Study. J Dent 2014; 42(5): 556-564.
(PMID: 24589846; DOI: 10.1016/j.jdent.2014.02.015)


8) Pinós T, Fuku N, Cámara Y, Arai Y, Abe Y, Rodríguez-Romo G, Garatachea N, Santos-Lozano A, Miro-Casas E, Ruiz-Meana M, Otaegui I, Murakami H, Miyachi M, Garcia-Dorado D, Hinohara K, Andreu AL, Kimura A, Hirose N, Lucia A. The rs1333049 polymorphism on locus 9p21.3 and extreme longevity in Spanish and Japanese cohorts. Age (Dordr) 2014; 36(2): 933-943.
(PMID: 24163049; DOI: 10.1007/s11357-013-9593-0)


9) da Rosa G, Martin P, Gondo Y, Hirose N, Ishioka Y, Poon LW; Georgia Centenarian Study. Examination of important life experiences of the oldest-old: cross-cultural comparisons of U.S. and Japanese centenarians. J Cross Cult Gerontol 2014; 29(2): 109-130.
(PMID: 24477838; DOI: 10.1007/s10823-014-9223-z)

<2013年以前>

1) Gondo Y, Arai Y, Hirose N. Wellbeing in the oldest old and centenarians in Japan. In Wellbeing in later life: Wellbeing: A Complete Reference Guide, volume IV. Ed Kirkwood TBL & Cooper CL. West Sussex, England, John Wiley & Sons, Ltd, 2013.


2) Takayama M, Arai Y, Sasaki S, Hashimoto M, Shimizu K, Abe Y, Hirose N. Association of marine-origin n-3 polyunsaturated fatty acids consumption and functional mobility in the community-dwelling oldest old. J Nutr Health Aging 2013; 17(1): 82-89.


3) Benigni A, Orisio S, Noris M, Iatropoulos P, Castaldi D, Kamide K, Rakugi H, Arai Y, Todeschini M, Ogliari G, Imai E, Gondo Y, Hirose N, Mari D, Remuzzi G.  Variations of the angiotensin II type 1 receptor gene are associated with extreme human longevity. Age (Dordr) 2013; 35(3): 993-1005.
(PMID: 22569962; DOI: 10.1007/s11357-012-9408-8)


4) Sebastiani P, Bae H, Sun FX, Andersen SL, Daw EW, Malovini A, Kojima T, Hirose N, Schupf N, Puca A, Perls TT. Meta-analysis of genetic variants associated with human exceptional longevity. Aging (Albany NY) 2013; 5(9): 653-661. (PMID: 24244950)


5) Robine JM, Herrmann FR, Arai Y, Willcox DC, Gondo Y, Hirose N, Suzuki M, Saito Y. Accuracy of the centenarian numbers in Okinawa and the role of the Okinawan diet on longevity: responses to Le Bourg about the article “Exploring the impact of climate on human longevity”. Exp Gerontol 2013; 48(8): 840-842. (PMID: 23711883; DOI: 10.1016/j.exger.2013.04.015)


6) Robine JM, Herrmann FR, Arai Y, Willcox DC, Gondo Y, Hirose N, Suzuki M, Saito Y. Exploring the impact of climate on human longevity. Exp Gerontol 2012; 47(9): 660-671.
(PMID: 22613089; DOI: 10.1016/j.exger.2012.05.009)


7) Yagi T, Kosakai A, Ito D, Okada Y, Akamatsu W, Nihei Y, Nabetani A, Ishikawa F, Arai Y, Hirose N, Okano H, Suzuki N. Establishment of induced pluripotent stem cells from centenarians for neurodegenerative disease research. PLoS One 2012; 7(7): e41572.
(PMID: 22848530; DOI: 10.1371/journal.pone.0041572)


8) Iinuma T, Arai Y, Fukumoto M, Takayama M, Abe Y, Asakura K, Nishiwaki Y, Takebayashi T, Iwase T, Komiyama K, Gionhaku N, Hirose N. Maximum occlusal force and physical performance in the oldest old: the Tokyo oldest old survey on total health. J Am Geriatr Soc 2012; 60(1): 68-76.
(PMID: 22211666; DOI: 10.1111/j.1532-5415.2011.03780.x)


9) Oguro R, Kamide K, Katsuya T, Akasaka H, Sugimoto K, Congrains A, Arai Y, Hirose N, Saitoh S, Ohishi M, Mira T, Rakugi H. A single nucleotide polymorphism of the adenosine deaminase, RNA-specific gene is associated with the serum triglyceride level, abdominal circumference, and serum adiponectin concentration. Exp Gerontol 2012; 47(2): 183-187. (PMID: 22210125; DOI: 10.1016/j.exger.2011.12.004)


10) Arai Y, Takayama M, Abe Y, Hirose N. Adipokines and aging. J Atheroscler Thromb 2011; 18(7): 545-550.
(PMID: 21551960; DOI: 10.5551/jat.7039)


11) Sumiya C, Arai Y, Takayama M, Abe Y, Hirose N, Asakura K, Nishiwaki Y, Takebayashi T. Vitamin D deficiency and lifestyle factors in the oldest old. J Am Geriatr Soc 2010; 58(11): 2242-2244.
(PMID: 21054317; DOI: 10.1111/j.1532-5415.2010.03122.x)


12) Miura Y, Sato Y, Arai Y, Abe Y, Takayama M, Toda T, Hirose N, Endo T. Proteomic analysis of plasma proteins in Japanese semisuper centenarians. Exp Gerontol 2011; 46(1): 81-85.
(PMID: 20951194; DOI: 10.1016/j.exger.2010.10.002)


13) Arai Y, Iinuma T, Takayama M, Takayama M, Abe Y, Fukuda R, Ando J, Ohta K, Hanabusa H, Asakura K, Nishiwaki Y, Gondo Y, Akiyama H, Komiyama K, Gionhaku N, Hirose N. The Tokyo Oldest Old survey on Total Health (TOOTH): a longitudinal cohort study of multidimensional components of health and well-being. BMC Geriatr 2010; 10: 35. (PMID: 20529368; DOI: 10.1186/1471-2318-10-35)


14) Sebastiani P, Montano M, Puca A, Solovieff N, Kojima T, Wang MC, Melista E, Meltzer M, Fischer SE, Andersen S, Hartley SH, Sedgewick A, Arai Y, Bergman A, Barzilai N, Terry DF, Riva A, Anselmi CV, Malovini A, Kitamoto A, Sawabe M, Arai T, Gondo Y, Steinberg MH, Hirose N, Atzmon G, Ruvkun G, Baldwin CT, Perls TT. RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans. PLoS One 2009; 4(12): e8210.
(PMID: 20011587; DOI: 10.1371/journal.pone.0008210)


15) Arai Y, Kojima T, Takayama M, Hirose N. The metabolic syndrome, IGF-1, and insulin action. Mol Cell Endocrinol 2009; 299(1): 124-128.
(PMID: 18672019; DOI: 10.1016/j.mce.2008.07.002)


16) Inagaki H, Gondo Y, Hirose N, Masui Y, Kitagawa K, Arai Y, Ebihara Y, Yamamura K, Takayama M, Nakazawa S, Shimizu K, Homma A. Cognitive function in Japanese centenarians according to the Mini-Mental State Examination. Dement Geriatr Cogn Disord 2009; 28(1): 6-12.
(PMID: 19602888; DOI: 10.1159/000228713)


17) Shimizu K, Hirose N, Takayama M, Arai Y, Gondo Y, Ebihara Y, Yamamura K, Nakazawa S, Inagaki H, Masui Y, Kitagawa K. Relationship between physical and cognitive function, blood pressure and serum lipid concentration in centenarians. Geriatr Gerontol Int 2008; 8(4): 300-302.
(PMID: 19149843; DOI: 10.1111/j.1447-0594.2008.00479.x)


18) Bilal E, Rabadan R, Alexe G, Fuku N, Ueno H, Nishigaki Y, Fujita Y, Ito M, Arai Y, Hirose N, Ruckenstein A, Bhanot G, Tanaka M. Mitochondrial DNA haplogroup D4a is a marker for extreme longevity in Japan. PLoS One 2008; 3(6): e2421.
(PMID: 18545700; DOI: 10.1371/journal.pone.0002421)


19) Arai Y, Takayama M, Gondo Y, Inagaki H, Yamamura K, Nakazawa S, Kojima T, Ebihara Y, Shimizu K, Masui Y, Kitagawa K, Takebayashi T, Hirose N. Adipose endocrine function, insulin-like growth factor-1 axis, and exceptional survival beyond 100 years of age. J Gerontol A Biol Sci Med Sci 2008; 63(11): 1209-1218.
(PMID: 19038836)


20) Takayama M, Hirose N, Arai Y, Gondo Y, Shimizu K, Ebihara Y, Yamamura K, Nakazawa S, Inagaki H, Masui Y, Kitagawa K. Morbidity of Tokyo-area centenarians and its relationship to functional status. J Gerontol A Biol Sci Med Sci 2007; 62(7): 774-782.
(PMID: 17634326)


21) Gondo Y, Hirose N, Arai Y, Inagaki H, Masui Y, Yamamura K, Shimizu K, Takayama M, Ebihara Y, Nakazawa S, Kitagawa K. Functional status of centenarians in Tokyo, Japan: developing better phenotypes of exceptional longevity. J Gerontol A Biol Sci Med Sci 2006; 61(3): 305-310.