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2021年

1) Sasaki T, Abe Y, Takayama M, Adachi T, Okano H, Hirose N, Arai Y. Association among extracellular superoxide dismutase genotype, plasma concentration, and comorbidity in the very old and centenarians. Sci Rep. 2021 Apr 20;11(1):8539.

(PMID: 33879836 PMCID: PMC8058336 DOI: 10.1038/s41598-021-87982-6)

2) Arai Y, Oguma Y, Abe Y, Takayama M, Hara A, Urushihara H, Takebayashi T. Behavioral changes and hygiene practices of older adults in Japan during the first wave of COVID-19 emergency. BMC Geriatr. 2021 Feb 24;21(1):137.

(PMID: 33627073 PMCID: PMC7903371 DOI: 10.1186/s12877-021-02085-1)

3) Osawa Y, Abe Y, Takayama M, Oguma Y, Arai Y. Physical activity and all-cause mortality and mediators of the association in the very old. Exp Gerontol. 2021 Apr 25;150:111374.

(PMID: 33905878 DOI: 10.1016/j.exger.2021.111374)

4) Palapar L, Kerse N, Rolleston A, den Elzen WPJ, Gussekloo J, Blom JW, Robinson L, Martin-Ruiz C, Duncan R, Arai Y, Takayama M, Teh R; TULIP Consortium. Anaemia and physical and mental health in the very old: An individual participant data meta-analysis of four longitudinal studies of ageing. Age Ageing. 2021 Jan 8;50(1):113-119.

(PMID: 32939533 DOI: 10.1093/ageing/afaa178)

5) Du Puy RS, Poortvliet RKE, Mooijaart SP, den Elzen WPJ, Jagger C, Pearce SHS, Arai Y, Hirose N, Teh R, Menzies O, Rolleston A, Kerse N, Gussekloo J. Outcomes of Thyroid Dysfunction in People Aged Eighty Years and Older: An Individual Patient Data Meta-Analysis of Four Prospective Studies (Towards Understanding Longitudinal International Older People Studies Consortium). Thyroid. 2021 Apr;31(4):552-562.

(PMID: 33012278 DOI: 10.1089/thy.2020.0567)

6) Zempo H, Kim SJ, Fuku N, Nishida Y, Higaki Y, Wan J, Yen K, Miller B, Vicinanza R, Miyamoto-Mikami E, Kumagai H, Naito H, Xiao J, Mehta HH, Lee C, Hara M, Patel YM, Setiawan VW, Moore TM, Hevener AL, Sutoh Y, Shimizu A, Kojima K, Kinoshita K, Arai Y, Hirose N, Maeda S, Tanaka K, Cohen P. Aging (Albany NY). 2021 Jan 19;13(2):1692-1717.

(MID: 33468709 PMCID: PMC7880332 DOI: 10.18632/aging.202529)

7) Albani V, Nishio K, Ito T, Kotronia E, Moynihan P, Robinson L, Hanratty B, Kingston A, Abe Y, Takayama M, Iinuma T, Arai Y, Ramsay SE. Associations of poor oral health with frailty and physical functioning in the oldest old: results from two studies in England and Japan. BMC Geriatr. 2021 Mar 18;21(1):187.

(PMID: 33736595 PMCID: PMC7977173 DOI: 10.1186/s12877-021-02081-5)

8) Tanaka K, Kabayama M, Sugimoto K, Akasaka H, Takami Y, Takeya Y, Yamamoto K, Sekiguchi T, Kiyoshige E, Akagi Y, Godai K, Yasumoto S, Masui Y, Gondo Y, Ikebe K, Arai Y, Ishizaki T, Rakugi H, Kamide K; SONIC study group. Association between uric acid and atherosclerosis in community-dwelling older people: The SONIC study. Geriatr Gerontol Int. 2021 Jan;21(1):94-101.

(PMID: 33166058 DOI: 10.1111/ggi.14081)

9) Kitamura M, Ikebe K, Kamide K, Gondo Y, Yamashita M, Takedachi M, Nozaki T, Fujihara C, Yamada S, Kashiwagi Y, Miki K, Iwayama T, Hatta K, Mihara Y, Kurushima Y, Takeshita H, Kabayama M, Oguro R, Kawai T, Akasaka H, Takeya Y, Yamamoto K, Sugimoto K, Ishizaki T, Arai Y, Masui Y, Takahashi R, Rakugi H, Maeda Y, Murakami S. Odontology. 2021 Apr;109(2):506-513.

(PMID: 33150559 DOI: 10.1007/s10266-020-00567-z)

10) Klinpudtan N, Kabayama M, Godai K, Gondo Y, Masui Y, Akagi Y, Srithumsuk W, Kiyoshige E, Sugimoto K, Akasaka H, Takami Y, Takeya Y, Yamamoto K, Ikebe K, Yasumoto S, Ogawa M, Inagaki H, Ishizaki T, Arai Y, Rakugi H, Kamide K. Arch Gerontol Geriatr. 2021 Mar 4;95:104386. (PMID: 33714872 DOI: 10.1016/j.archger.2021.104386)

2020年

1) Hirata T, Arai Y, Yuasa S, Abe Y, Takayama M, Sasaki T, Kunitomi A, Inagaki H, Endo M, Morinaga J, Yoshimura K, Adachi T, Oike Y, Takebayashi T, Okano H, Hirose N. Associations of cardiovascular biomarkers and plasma albumin with exceptional survival to the highest ages. Nat Commun. 2020 Jul 30;11(1):3820. (PMID: 32732919 DOI: 10.1038/s41467-020-17636-0)

2) Sasaki T, Nishimoto Y, Abe Y, Takayama M, Hirose N, Okano H, Arai Y. Sex-Specific Effects of Apolipoprotein ε4 Allele on Mortality in Very Old and Centenarian Japanese Men. J Gerontol A Biol Sci Med Sci. 2020 Sep 25;75(10):1874-1879. ( PMID: 31603980 DOI: 10.1093/gerona/glz242)

3) Noma T, Kabayama M, Gondo Y, Yasumoto S, Masui Y, Sugimoto K, Akasaka H, Godai K, Higuchi A, Akagi Y, Takami Y, Takeya Y, Yamamoto K, Ikebe K, Arai Y, Ishizaki T, Rakugi H, Kamide K. Association of anemia and SRH in older people: the SONIC study. Geriatr Gerontol Int. 2020 Jul;20(7):720-726. (PMID: 32515163 DOI: 10.1111/ggi.13945)

4) Srithumsuk W, Kabayama M, Godai K, Klinpudtan N, Sugimoto K, Akasaka H, Takami Y, Takeya Y, Yamamoto K, Yasumoto S, Gondo Y, Arai Y, Masui Y, Ishizaki T, Shimokata H, Rakugi H, Kamide K. Association between physical function and long-term care in community-dwelling older and oldest people: the SONIC study. Environ Health Prev Med. 2020 Sep 1;25(1):46.

(PMID: 32873231 PMCID: PMC7465312 DOI: 10.1186/s12199-020-00884-3)

5) Kabayama M, Kamide K, Gondo Y, Masui Y, Nakagawa T, Ogawa M, Yasumoto S, Ryuno H, Akagi Y, Kiyoshige E, Godai K, Sugimoto K, Akasaka H, Takami Y, Takeya Y, Yamamoto K, Ikebe K, Inagaki H, Martin P, Arai Y, Ishizaki T, Rakugi H; SONIC study group. The association of blood pressure with physical frailty and cognitive function in community-dwelling septuagenarians, octogenarians, and nonagenarians: the SONIC study. Hypertens Res. 2020 Dec;43(12):1421-1429. (PMID: 32641853 DOI: 10.1038/s41440-020-0499-9)

6) Arai Y. G6PD Deficiency: A Possible Cardiovascular Risk Factor in Older People. J Atheroscler Thromb. 2020 Dec 23. doi: 10.5551/jat.ED152. (PMID: 33361648)

7) Fujita H, Sasaki T, Miyamoto T, Akutsu SN, Sato S, Mori T, Nakabayashi K, Hata K, Suzuki H, Kosaki K, Matsuura S, Matsubara Y, Amagai M, Kubo A. Premature aging syndrome showing random chromosome number instabilities with CDC20 mutation.  Aging Cell. 2020 19(11):e13251. (PMID: 33094908  PMCID: PMC7681047  DOI: 10.1111/acel.13251) 

2019年

1) Arai Y, Kamide K, Hirose N. Adipokines and Aging: Findings from Centenarians and the Very Old. Front. Endocrinol. 14 March 2019 |
(PMID: 30923512 PMCID: (PMC6426744 DOI: 10.3389/fendo.2019.00142)

2) Sasaki T, Nishimoto Y, Abe Y, Takayama M, Hirose N, Okano H, Arai Y. Sex-specific effects of apolipoprotein ε4 allele on mortality in very old and centenarian Japanese men. J Gerontol A Biol Sci Med Sci. 2019 Oct 11.
(PMID: 31603980 DOI: 10.1093/gerona/glz242)

3) Hashimoto K, Kouno T, Ikawa T, Hayatsu N, Miyajima Y, Yabukami H, Terooatea T, Sasaki T, Suzuki T, Valentine M, Pascarella G, Okazaki Y, Suzuki H, Shin JW, Minoda A, Taniuchi I, Okano H, Arai Y, Hirose N, Carninci P. Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians. Proc Natl Acad Sci U S A. 2019 Nov 26;116(48):24242-24251.
(MID: 31719197 PMCID: PMC6883788 DOI: 10.1073/pnas.1907883116)

4) Martin P, Gondo Y, Arai Y, Ishioka Y, Johnson MA, Miller LS, Woodard JL, Poon LW, Hirose N. Cardiovascular health and cognitive functioning among centenarians: a comparison between the Tokyo and Georgia centenarian studies. Int Psychogeriatr. 2019;31(4):455-465.
(PMID: 30786950 PMCID: PMC6483832 DOI: 10.1017/S1041610218001813)

5) Godai K, Kabayama M, Gondo Y, Yasumoto S, Sekiguchi T, Noma T, Tanaka K, Kiyoshige E, Akagi Y, Sugimoto K, Akasaka H, Takami Y, Takeya Y, Yamamoto K, Arai Y, Masui Y, Ishizaki T, Ikebe K, Satoh M, Asayama K, Ohkubo T, Rakugi H, Kamide K; SONIC study group. Day-to-day blood pressure variability is associated with lower cognitive performance among the Japanese community-dwelling oldest-old population: the SONIC study. Hypertens Res. 2019 Dec 19.
(PMID: 31853044 DOI: 10.1038/s41440-019-0377-5)

6) Mihara Y, Matsuda KI, Takahashi T, Hatta K, Fukutake M, Sato H, Gondo Y, Masui Y, Kamide K, Sugimoto K, Kabayama M, Ishizaki T, Arai Y, Maeda Y, Ikebe K. Occlusal support predicts tooth loss in older Japanese people. Community Dent Oral Epidemiol. 2019 Dec 26.
(PMID: 31876315 DOI: 10.1111/cdoe.12515)

7) Matsuzawa Y, Iwatsuki-Horimoto K, Nishimoto Y, Abe Y, Fukuyama S, Hamabata T, Okuda M, Go Y, Watanabe T, Imai M, Arai Y, Fouchier RAM, Yamayoshi S, Kawaoka Y. Antigenic Change in Human Influenza A(H2N2) Viruses Detected by Using Human Plasma from Aged and Younger Adult Individuals. Viruses. 2019; 11(11). pii: E978.
(PMID: 31652870 PMCID: PMC6893718 DOI: 10.3390/v11110978)

8) Hiraide T, Kataoka M, Suzuki H, Aimi Y, Chiba T, Isobe S, Katsumata Y, Goto S, Kanekura K, Yamada Y, Moriyama H, Kitakata H, Endo J, Yuasa S, Arai Y, Hirose N, Satoh T, Hakamata Y, Sano M, Gamou S, Kosaki K, Fukuda K. Poor outcomes in carriers of the RNF213 variant (p.Arg4810Lys) with pulmonary arterial hypertension. J Heart Lung Transplant. 2019; pii: S1053-2498(19)31667-5.
(PMID: 31542298 DOI: 10.1016/j.healun.2019.08.022)

9) Sala G, Jopp D, Gobet F, Ogawa M, Ishioka Y, Masui Y, Inagaki H, Nakagawa T, Yasumoto S, Ishizaki T, Arai Y, Ikebe K, Kamide K, Gondo Y. The impact of leisure activities on older adults’ cognitive function, physical function, and mental health. PLoS One. 2019 Nov 8;14(11):e0225006.
(PMID: 31703115 PMCID: PMC6839878 DOI: 10.1371/journal.pone.0225006)

10) Sebastiani P, Gurinovich A, Nygaard M, Sasaki T, Sweigart B, Bae H, Andersen SL, Villa F, Atzmon G, Christensen K, Arai Y, Barzilai N, Puca A, Christiansen L, Hirose N, Perls TT. APOE Alleles and Extreme Human Longevity. J Gerontol A Biol Sci Med Sci. 2019 Jan 1;74(1):44-51.
(PMID: 30060062 PMCID: PMC6298189 DOI: 10.1093/gerona/gly174)

11) Eguchi Y, Noda Y, Nakajima S, Tsugawa S, Kida H, Plitman E, Graff-Guerrero A, Chakravarty MM, Takayama M, Arai Y, Matsuda H, Mimura M, Niimura H. Subiculum volumes associated with memory function in the oldest-old individuals aged 95 years and older. Geriatr Gerontol Int. 2019; 19(4):347-351.
(PMID: 30803149 DOI: 10.1111/ggi.13614)

12) Fukutake M, Ikebe K, Okubo H, Matsuda KI, Enoki K, Inomata C, Takeshita H, Mihara Y, Hatta K, Gondo Y, Kamide K, Masui Y, Ishizaki T, Arai Y, Maeda Y. Relationship between oral stereognostic ability and dietary intake in older Japanese adults with complete dentures. J Prosthodont Res. 2019; 63(1):105-109.
(PMID: 30385332 DOI: 10.1016/j.jpor.2018.10.001)

13) Okubo H, Murakami K, Inagaki H, Gondo Y, Ikebe K, Kamide K, Masui Y, Arai Y, Ishizaki T, Sasaki S, Nakagawa T, Kabayama M, Sugimoto K, Rakugi H, Maeda Y; SONIC Study Group. Hardness of the habitual diet and its relationship with cognitive function among 70-year-old Japanese elderly: Findings from the SONIC Study. J Oral Rehabil. 2019; 46(2):151-160.
(PMID: 30325532 DOI: 10.1111/joor.12731)

14) Hatta K, Ikebe K, Mihara Y, Gondo Y, Kamide K, Masui Y, Sugimoto K, Matsuda KI, Fukutake M, Kabayama M, Shintani A, Ishizaki T, Arai Y, Rakugi H, Maeda Y. Lack of posterior occlusal support predicts the reduction in walking speed in 80-year-old Japanese adults: A 3-year prospective cohort study with propensity score analysis by the SONIC Study Group. Gerodontology. 2019.
(PMID: 30724390 DOI: 10.1111/ger.12393)

15) Kiyoshige E, Kabayama M, Gondo Y, Masui Y, Ryuno H, Sawayama Y, Inoue T, Akagi Y, Sekiguchi T, Tanaka K, Nakagawa T, Yasumoto S, Ogawa M, Inagaki H, Oguro R, Sugimoto K, Akasaka H, Yamamoto K, Takeya Y, Takami Y, Itoh N, Takeda M, Nagasawa M, Yokoyama S, Maeda S, Ikebe K, Arai Y, Ishizaki T, Rakugi H, Kamide K. Association between long-term care and chronic and lifestyle-related disease modified by social profiles in community-dwelling people aged 80 and 90; SONIC study. Arch Gerontol Geriatr. 2019;81:176-181.
(PMID: 30597340 DOI: 10.1016/j.archger.2018.12.010)

16) Maeda S, Takeya Y, Oguro R, Akasaka H, Ryuno H, Kabayama M, Yokoyama S, Nagasawa M, Fujimoto T, Takeda M, Onishi-Takeya M, Itoh N, Takami Y, Yamamoto K, Sugimoto K, Inagaki H, Ogawa M, Nakagawa T, Yasumoto S, Masui Y, Arai Y, Ishizaki T, Ikebe K, Gondo Y, Kamide K, Rakugi H. Serum albumin/globulin ratio is associated with cognitive function in community-dwelling older people: The Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians study. Geriatr Gerontol Int. 2019 Oct;19(10):967-971.
(PMID: 31461209 DOI: 10.1111/ggi.13751)

17) Tanaka A, Arai Y, Hirata T, Abe Y, Oguma Y, Urushihara N. Effects of Polypharmacy and Anticholinergic/Sedative Drugs on the Physical/Cognitive/Mental Related Outcomes of Community-Dwelling Elderly People: The Kawasaki Wellbeing Project [Japanese]. Nihon Ronen Igakkai Zasshi. 2019; 56(4); 504-515.
(PMID: 31761857 DOI: 10.3143/geriatrics.56.504)

18) Sasaki T, Nishimoto Y, Hirose N, Arai Y. Genetic Protective Factors for Dementia Isolated by Centenarian Researches. Brain Nerve. [Review. Japanese.] 71(10):1061-1070 (2019).
(PMID: 31588050 DOI: 10.11477/mf.1416201405)

2018年

1) Okada Y, Momozawa Y, Sakaue S, Kanai M, Ishigaki K, Akiyama M, Kishikawa T, Arai Y, Sasaki T, Kosaki K, Suematsu M, Matsuda K, Yamamoto K, Kubo M, Hirose N, Kamatani Y. Deep whole-genome sequencing reveals recent selection signatures linked to evolution and disease risk of Japanese. Nat Commun. 2018 Apr 24;9(1):1631.
(PMID: 29691385 PMCID: PMC5915442 DOI: 10.1038/s41467-018-03274-0)

2) Miura Y, Hashii N, Ohta Y, Itakura Y, Tsumoto H, Suzuki J, Takakura D, Abe Y, Arai Y, Toyoda M, Kawasaki N, Hirose N, Endo T. Characteristic glycopeptides associated with extreme human longevity identified through plasma glycoproteomics. Biochim Biophys Acta. 2018 Mar 24;1862(6):1462-1471.
(PMID: 29580922 DOI: 10.1016/j.bbagen.2018.03.025)

3) Kobayashi S, Yuan X, Sasaki S, Osawa Y, Hirata T, Abe Y, Takayama M, Arai Y, Masui Y, Ishizaki T. Relative validity of brief-type self-administered diet history questionnaire among very old Japanese aged 80 years or older. Public Health Nutr. 2018 Oct 2:1-11.
(PMID: 30274565 PMCID: PMC6414039 DOI: 10.1017/S1368980018002331)

4) Martin P, Gondo Y, Arai Y, Ishioka Y, Woodard JL, Poon LW, Hirose N. Physical, sensory, and cognitive functioning among centenarians: a comparison between the Tokyo and Georgia centenarian studies. Qual Life Res. 2018;27(11):3037-3046.
(PMID: 30051258 DOI: 10.1007/s11136-018-1943-z)

5) Eguchi Y, Tasato K, Nakajima S, Noda Y, Tsugawa S, Shinagawa S, Niimura H, Hirose N, Arai Y, Mimura M. Relationships between socio-clinico-demographic factors and global cognitive function in the oldest old living in the Tokyo Metropolitan area: Reanalysis of the Tokyo Oldest Old Survey on Total Health (TOOTH). Int J Geriatr Psychiatry. 2018 Mar 7.
(PMID: 29514399 DOI: 10.1002/gps.4873)

6) Nagasawa M, Takami Y, Akasaka H, Kabayama M, Maeda S, Yokoyama S, Fujimoto T, Nozato Y, Imaizumi Y, Takeda M, Itoh N, Takeya Y, Yamamoto K, Sugimoto K, Nakagawa T, Masui Y, Arai Y, Ishizaki T, Ikebe K, Gondo Y, Kamide K, Rakugi H. High plasma adiponectin levels are associated with frailty in a general old-old population: The Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians study. Geriatr Gerontol Int. 2018 Feb 2.
(PMID: 29392822 DOI: 10.1111/ggi.13258)

7) Ikebe K, Gondo Y, Kamide K, Masui Y, Ishizaki T, Arai Y, Inagaki H, Nakagawa T, Kabayama M, Ryuno H, Okubo H, Takeshita H, Inomata C, Kurushima Y, Mihara Y, Hatta K, Fukutake M, Enoki K, Ogawa T, Matsuda KI, Sugimoto K, Oguro R, Takami Y, Itoh N, Takeya Y, Yamamoto K, Rakugi H, Murakami S, Kitamura M, Maeda Y. Occlusal force is correlated with cognitive function directly as well as indirectly via food intake in community-dwelling older Japanese: From the SONIC study. PLoS One. 2018 Jan 5;13(1):e0190741.
(PMID: 29304177 PMCID: PMC5755890 DOI: 10.1371/journal.pone.0190741)

8) Fukutake M, Ogawa T, Ikebe K, Mihara Y, Inomata C, Takeshita H, Matsuda K, Hatta K, Gondo Y, Masui Y, Inagaki H, Arai Y, Kamide K, Ishizaki T, Maeda Y. Impact of cognitive function on oral perception in independently living older people. Clin Oral Investig. 2019; 23 (1), 267-271.
(PMID: 29637315 DOI: 10.1007/s00784-018-2433-y)

9) Mihara Y, Matsuda KI, Hatta K, Gondo Y, Masui Y, Nakagawa T, Kamide K, Ishizaki T, Arai Y, Maeda Y, Ikebe K. Relationship between gerotranscendence and oral health-related quality of life. J Oral Rehabil. 2018;45(10):805-809.
(PMID: 30019445 DOI: 10.1111/joor.12691)

10) Arai Y, Hirose N. Biomedical characteristics of Supercentenarians. [Japanese]. Nihon Ronen Igakkai Zasshi. 2018; 55: 578-583.
(PMID: 30542023 doi: 10.3143/geriatrics.55.578)

2017年

1) Tanisawa K, Hirose N, Arai Y, Shimokata H, Yamada Y, Kawai H, Kojima M, Obuchi S, Hirano H, Suzuki H, Fujiwara Y, Taniguchi Y, Shinkai S, Ihara K, Sugaya M, Higuchi M, Arai T, Mori S, Sawabe M, Sato N, Muramatsu M, Tanaka M. Inverse association between height-increasing alleles and extreme longevity in Japanese women. J Gerontol A Biol Sci Med Sci 2017 (in press)
(PMID: 28958036; DOI: 10.1093/gerona/glx155)

2)  Gondo Y, Hirose N, Yasumoto S, Arai Y, Saito Y. Age verification of the longest lived man in the world. Exp Gerontol 2017 (in press)
(PMID: 28847724; DOI: 10.1016/j.exger.2017.08.030)

3)  Hirata T, Arai Y, Takayama M, Abe Y, Okuma K, Takebayashi T. Carotid plaque score and risk of cardiovascular mortality in the oldest old: Results from the TOOTH study. J Atheroscler Thromb 2017 (in press)
(PMID: 28179606; DOI: 10.5551/jat.37911)

4)  Nakagawa T, Cho J, Gondo Y, Martin P, Johnson MA, Poon LW, Hirose N. Subjective well-being in centenarians: a comparison of Japan and the United States. Aging Ment Health 2017 (in press)
(PMID: 28682113; DOI: 10.1080/13607863.2017.1348477)

5) Okubo H, Inagaki H, Gondo Y, Kamide K, Ikebe K, Masui Y, Arai Y, Ishizaki T, Sasaki S, Nakagawa T, Kabayama M, Sugimoto K, Rakugi H, Maeda Y; SONIC study group. Association between dietary patterns and cognitive function among 70-year-old Japanese elderly: a cross-sectional analysis of the SONIC study. Nutr J 2017; 16: 56.
(PMID: 28893250; DOI: 10.1186/s12937-017-0273-2)

6) Sato R, Arai Y, Abe Y, Takayama M, Urushihara H. The drug burden of anticholinergics and sedatives and influence on outcomes in the community-living oldest old: The Tokyo Oldest Old survey on Total Health (TOOTH) survey. Nihon Ronen Igakkai Zasshi 2017; 54: 403-416 [Japanese].
(PMID: 28855465; DOI: 10.3143/geriatrics.54.403)

7) Tada S, Ikebe K, Kamide K, Gondo Y, Inomata C, Takeshita H, Matsuda KI, Kitamura M, Murakami S, Kabayama M, Oguro R, Nakama C, Kawai T, Yamamoto K, Sugimoto K, Shintani A, Ishihara T, Arai Y, Masui Y, Takahashi R, Rakugi H, Maeda Y. Relationship between atherosclerosis and occlusal support of natural teeth with mediating effect of atheroprotective nutrients: From the SONIC study. PLoS One 2017; 12: e0182563.
(PMID: 28817589; DOI: 10.1371/journal.pone.0182563)

8) Arai Y, Sasaki T, Hirose N. Demographic, phenotypic, and genetic characteristics of centenarians in Okinawa and Honshu, Japan: Part 2 Honshu, Japan. Mech Ageing Dev 2017; 165: 80-85.
(PMID: 28214534; DOI: 10.1016/j.mad.2017.02.005)

9) Iinuma T, Hirata T, Arai Y, Takayama M, Abe Y, Fukumoto M, Fukui Y, Gionhaku N. Perceived swallowing problems and mortality risk in very elderly people ≥85 years old: Results of the Tokyo Oldest Old Survey on Total Health study. Gerodontology 2017; 34: 313-319.
(PMID: 28349594; DOI: 10.1111/ger.12265)

10) Arai Y. The prevalence and risk factors of dementia in centenarians. Brain Nerve 2017; 69(7): 771-780 [Japanese].
(PMID: 28739991; DOI: 10.11477/mf.1416200819)

11) Arai Y. Aging and homeostasis. Biomedical peculiarities of semi-supercentenarians. Clin Calcium 2017; 27(7): 969-974 [Japanese].
(PMID: 28649103; DOI: CliCa1707969974)

12) Iinuma T, Arai Y, Takayama M, Takayama M, Abe Y, Osawa Y, Fukumoto M, Fukui Y, Shioda Y, Hirose N, Komiyama K, Gionhaku N. Satisfaction with dietary life affects oral health-related quality of life and subjective well-being in very elderly people. J Oral Sci 2017; 59(2): 207-213.
(PMID: 28637980; DOI: 10.2334/josnusd.16-0414)

13) Osawa Y, Arai Y, Takayama M, Hirata T, Kawasaki M, Abe Y, Iinuma T, Sasaki S, Hirose N. Identification of dietary patterns and their relationships with general and oral health in the very old. Asia Pac J Clin Nutr 2017; 26(2): 262-270.
(PMID: 28244704; DOI: 10.6133/apjcn.022016.02)

14) Ryuno H, Kamide K, Gondo Y, Kabayama M, Oguro R, Nakama C, Yokoyama S, Nagasawa M, Maeda-Hirao S, Imaizumi Y, Takeya M, Yamamoto H, Takeda M, Takami Y, Itoh N, Takeya Y, Yamamoto K, Sugimoto K, Nakagawa T, Yasumoto S, Ikebe K, Inagaki H, Masui Y, Takayama M, Arai Y, Ishizaki T, Takahashi R, Rakugi H. Longitudinal association of hypertension and diabetes mellitus with cognitive functioning in a general 70-year-old population: the SONIC study. Hypertens Res 2017; 40(7): 665-670.
(PMID: 28230198; DOI: 10.1038/hr.2017.15)

15) Oguma Y, Osawa Y, Takayama M, Abe Y, Tanaka S, Lee IM, Arai Y. Validation of questionnaire-assessed physical activity in comparison with objective measures using accelerometers and physical performance measures among community-dwelling adults aged ≥85 years in Tokyo, Japan. J Phys Act Health 2017; 14(4): 245-252.
(PMID: 27918699; DOI: 10.1123/jpah.2016-0208)

16) Osawa Y, Arai Y, Oguma Y, Hirata T, Abe Y, Azuma K, Takayama M, Hirose N. Relationships between anterior thigh muscle echo intensity and physical activity and functional mobility in a very old population. J Aging Phys Act 2017; 25(2): 189-195.
(PMID: 27623344; DOI: 10.1123/japa.2015-0203)

17) Tanisawa K, Arai Y, Hirose N, Shimokata H, Yamada Y, Kawai H, Kojima S, Obuchi S, Hirano H, Yoshida H, Suzuki H, Fujiwara Y, Ihara K, Sugaya M, Arai T, Mori S, Sawabe M, Sato N, Muramatsu M, Higuchi M, Liu YW, Kong QP, Tanaka M. Exome-wide association study identifies CLEC3B missense variant p.S106G as being associated with extreme longevity in East Asian populations. J Gerontol A Biol Sci Med Sci 2017; 72(3): 309-318.
(PMID: 27154906; DOI: 10.1093/gerona/glw074)

18) Ogawa T, Uota M, Ikebe K, Arai Y, Kamide K, Gondo Y, Masui Y, Ishizaki T, Inomata C, Takeshita H, Mihara Y, Hatta K, Maeda Y. Longitudinal study of factors affecting taste sense decline in old-old individuals. J Oral Rehabil 2017; 44(1): 22-29.
(PMID: 27748531; DOI: 10.1111/joor.12454)

2016年

1) Santos-Lozano A, Pareja-Galeano H, Fuku N, Hirose N, Emanuele E, Lucia A, Sanchis-Gomar F. Implications of obesity in exceptional longevity. Ann Transl Med 2016; 4: 416.
(PMID: 27867968)

2) Fuku N, Alis R, Yvert T, Zempo H, Naito H, Abe Y, Arai Y, Murakami H,Miyachi M, Pareja-Galeano H, Emanuele E, Hirose N, Lucia A. Muscle-related polymorphisms (MSTN rs1805086 and ACTN3 rs1815739) are not associated with exceptional longevity in Japanese centenarians. PLoS One 2016; 11: e0166605.
(PMID: 27861536; DOI: 10.1371/journal.pone.0166605)

3) Fuku N, Díaz-Peña R, Arai Y, Abe Y, Pareja-Galeano H, Sanchis-Gomar F, Santos-Lozano A, Zempo H, Naito H, Murakami H, Miyachi M, Venturini L, Ricevuti G, Hirose N, Emanuele E, Lucia A. Rs2802292 polymorphism in the FOXO3A gene and exceptional longevity in two ethnically distinct cohorts. Maturitas 2016; 92: 110-114.
(PMID: 27621247; DOI: 10.1016/j.maturitas.2016.07.016)

4) Uota M, Ogawa T, Ikebe K, Arai Y, Kamide K, Gondo Y, Masui Y, Ishizaki T, Inomata C, Takeshita H, Mihara Y, Maeda Y. Factors related to taste sensitivity in elderly: cross-sectional findings from SONIC study. J Oral Rehabil 2016; 43(12): 943-952.
(PMID: 27627583; DOI: 10.1111/joor.12442)

5) Takao M, Hirose N, Arai Y, Mihara B, Mimura M. Neuropathology of supercentenarians – four autopsy case studies. Acta Neuropathol Commun 2016; 4(1): 97.
(PMID: 27590044; DOI: 10.1186/s40478-016-0368-6)

6) Iinuma T, Arai Y, Takayama M, Abe Y, Ito T, Kondo Y, Hirose N, Gionhaku N. Association between maximum occlusal force and 3-year all-cause mortality in community-dwelling elderly people. BMC Oral Health 2016; 16(1): 82.
(PMID: 27586200; DOI: 10.1186/s12903-016-0283-z)

7) Ishioka YL, Gondo Y, Fuku N, Inagaki H, Masui Y, Takayama M, Abe Y, Arai Y, Hirose N. Effects of the APOE ε4 allele and education on cognitive function in Japanese centenarians. Age (Dordr) 2016; 38(5-6): 495-503.
(PMID: 27558117; DOI: 10.1007/s11357-016-9944-8)

8) Brodaty H, Woolf C, Andersen S, Barzilai N, Brayne C, Cheung KS, Corrada MM, Crawford JD, Daly C, Gondo Y, Hagberg B, Hirose N, Holstege H, Kawas C, Kaye J, Kochan NA, Lau BH, Lucca U, Marcon G, Martin P, Poon LW, Richmond R, Robine JM, Skoog I, Slavin MJ, Szewieczek J, Tettamanti M, Vina J, Perls T, Sachdev PS. ICC-dementia (International Centenarian Consortium-dementia): an international consortium to determine the prevalence and incidence of dementia in centenarians across diverse ethnoracial and sociocultural groups. BMC Neurol 2016; 16: 52.
(PMID: 27098177; DOI: 10.1186/s12883-016-0569-4)

9) Ryuno H, Kamide K, Gondo Y, Nakama C, Oguro R, Kabayama M, Kawai T, Kusunoki H, Yokoyama S, Imaizumi Y, Takeya M, Yamamoto H, Takeda M, Takami Y, Itoh N, Yamamoto K, Takeya Y, Sugimoto K, Nakagawa T, Ikebe K, Inagaki H, Masui Y, Ishizaki T, Takayama M, Arai Y, Takahashi R, Rakugi H. Differences in the association between high blood pressure and cognitive functioning among the general Japanese population aged 70 and 80 years: The SONIC Study. Hypertens Res 2016; 39(7): 557-563. (PMID: 27009579; DOI: 10.1038/hr.2016.25)

10) Kawasaki M, Arai Y, Takayama M, Hirata T, Takayama M, Abe Y, Niimura H, Mimura M, Takebayashi T, Hirose N. Carotid atherosclerosis, cytomegalovirus infection, and cognitive decline in the very old: a community-based prospective cohort study. Age (Dordr) 2016; 38(2): 29.
(PMID: 26886582; DOI: 10.1007/s11357-016-9890-5)

11) Morris BJ, Chen R, Donlon TA, Evans DS, Tranah GJ, Parimi N, Ehret GB, Newton-Cheh C, Seto T, Willcox DC, Masaki KH, Kamide K, Ryuno H, Oguro R, Nakama C, Kabayama M, Yamamoto K, Sugimoto K, Ikebe K, Masui Y, Arai Y, Ishizaki T, Gondo Y, Rakugi H, Willcox BJ. Association analysis of FOXO3 longevity variants with blood pressure and essential hypertension. Am J Hypertens 2016; 29(11): 1292-1300.
(PMID: 26476085; DOI: 10.1093/ajh/hpv171)

12) Yoshinaka M, Ikebe K, Uota M, Ogawa T, Okada T, Inomata C, Takeshita H, Mihara Y, Gondo Y, Masui Y, Kamide K, Arai Y, Takahashi R, Maeda Y. Age and sex differences in the taste sensitivity of young adult, young-old and old-old Japanese. Geriatr Gerontol Int 2016; 16(12): 1281-1288.
(PMID: 26493051; DOI: 10.1111/ggi.12638)

2015年

1) Arai Y, Martin-Ruiz CM, Takayama M, Abe Y, Takebayashi T, Koyasu S, Suematsu M, Hirose N, von Zglinicki T. Inflammation, but not telomere length, predicts successful ageing at extreme old age: a longitudinal study of semi-supercentenarians. EBioMedicine 2015; 2(10): 1549-1558.
(PMID: 26629551; DOI: 10.1016/j.ebiom.2015.07.029)

2) Iinuma T, Arai Y, Abe Y, Takayama M, Fukumoto M, Fukui Y, Iwase T, Takebayashi T, Hirose N, Gionhaku N, Komiyama K. Denture wearing during sleep doubles the risk of pneumonia in the very elderly. J Dent Res 2015; 94(3 Suppl): 28S-36S.
(PMID: 25294364; DOI: 10.1177/0022034514552493)

3) Miura Y, Hashii N, Tsumoto H, Takakura D, Ohta Y, Abe Y, Arai Y, Kawasaki N, Hirose N, Endo T; SONIC (Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians). Change in N-glycosylation of plasma proteins in Japanese semisupercentenarians. PLoS One 2015; 10(11): e0142645.
(PMID: 26559536; DOI: 10.1371/journal.pone.0142645)

4) Fuku N, He ZH, Sanchis-Gomar F, Pareja-Galeano H, Tian Y, Arai Y, Abe Y, Murakami H, Miyachi M, Zempo H, Naito H, Yvert T, Verde Z, Venturini L, Fiuza-Luces C, Santos-Lozano A, Rodriguez-Romo G, Ricevuti G, Hirose N, Emanuele E, Garatachea N, Lucia A. Exceptional longevity and muscle and fitness related genotypes: a functional in vitro analysis and case-control association replication study with SNPs THRH rs7832552, IL6 rs1800795, and ACSL1 rs6552828. Front Aging Neurosci 2015; 7: 59.
(PMID: 25999849; DOI: 10.3389/fnagi.2015.00059)

5) Takeshita H, Ikebe K, Kagawa R, Okada T, Gondo Y, Nakagawa T, Ishioka Y, Inomata C, Tada S, Matsuda K, Kurushima Y, Enoki K, Kamide K, Masui Y, Takahashi R, Arai Y, Maeda Y. Association of personality traits with oral health-related quality of life independently of objective oral health status: a study of community-dwelling elderly Japanese. J Dent 2015; 43(3):342-349.
(PMID: 25542999; DOI: 10.1016/j.jdent.2014.12.011)

6) Fuku N, Pareja-Galeano H, Zempo H, Alis R, Arai Y, Lucia A, Hirose N. The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity? Aging Cell 2015; 14(6): 921-923.
(PMID: 26289118; DOI: 10.1111/acel.12389)

7) Okada T, Ikebe K, Kagawa R, Inomata C, Takeshita H, Gondo Y, Ishioka Y, Okubo H, Kamide K, Masui Y, Takahashi R, Arai Y, Thomson WM, Maeda Y. Lower protein intake mediates association between lower occlusal force and slower walking speed: from the Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians Study. J Am Geriatr Soc 2015; 63(11): 2382-2387.
(PMID: 26503826; DOI: 10.1111/jgs.13784)

8) Arai Y, Takayama M, Inagaki H, Gondo Y, Masui Y, Hirose N. Centenarian Studies: An Interdisciplinary Research on Healthy Longevity. In Aging Mechanism: Longevity, metabolism, and brain aging. Ed Mori N & Mook-Jung I. Springer, German, 2015.

9) Ishioka Y, Gondo Y, Masui Y, Nakagawa T, Tabuchi M, Ogawa M, Kamide K, Ikebe K, Arai Y, Ishizaki T, Takahashi R. Occupational complexity and late-life memory and reasoning abilities. Shinrigaku Kenkyu 2015; 86(3): 219-229 [Japanese].
(PMID: 26402953)

10) Congrains A, Kamide K, Hirose N, Arai Y, Oguro R, Nakama C, Imaizumi Y, Kawai T, Kusunoki H, Yamamoto H, Onishi-Takeya M, Takeya Y, Yamamoto K, Sugimoto K, Akasaka H, Saitoh S, Miura T, Awata N, Kato N, Katsuya T, Ikebe K, Gondo Y, Rakugi H. Disease-associated polymorphisms in 9p21 are not associated with extreme longevity. Geriatr Gerontol Int 2015; 15(6): 797-803.
(PMID: 25257646; DOI: 10.1111/ggi.12346)

2014年

1) Arai Y, Inagaki H, Takayama M, Abe Y, Saito Y, Takebayashi T, Gondo Y, Hirose N. Physical independence and mortality at the extreme limit of lifespan: Supercentenarians study in Japan. J Gerontol A Bio Sci Med Sci 2014; 69(4): 486-494.
(PMID: 24225329; DOI: 10.1093/gerona/glt146)

2) Sanchis-Gomar F, Garatachea N, He ZH, Pareja-Galeano H, Fuku N, Tian Y, Arai Y, Abe Y, Murakami H, Miyachi M, Yvert T, Santiago C, Venturini L, Fiuza-Luces C, Santos-Lozano A, Rodríguez-Romo G, Ricevuti G, Hirose N, Emanuele E, Lucia A. FNDC5 (irisin) gene and exceptional longevity: a functional replication study with rs16835198 and rs726344 SNPs. Age (Dordr) 2014; 36(6): 9733.
(PMID: 25427998; DOI: 10.1007/s11357-014-9733-1)

3) Horio E, Kadomatsu T, Miyata T, Arai Y, Hosokawa K, Doi Y, Ninomiya T, Horiguchi Y, Endo M, Tabata M, Tazume H, Tian Z, Takahashi O, Terada K, Takeya M, Hao H, Hirose N, Minami T, Suda T, Kiyohara Y, Ogawa H, Kaikita K, Oike Y. The role of endothelial cell-derived angptl2 in vascular inflammation leading to endothelial dysfunction and atherosclerosis progression. Arterioscler Thromb Vasc Biol 2014; 34(4): 790-800.
(PMID: 24526691; DOI: 10.1161/ATVBAHA.113.303116)

4) Garatachea N, Emanuele E, Calero M, Fuku N, Arai Y, Abe Y, Murakami H, Miyachi M, Yvert T, Verde Z, Zea MA, Venturini L, Santiago C, Santos-Lozano A, Rodríguez G, Ricevuti G, Hirose N, Rábano A, Lucia A. ApoE gene and exceptional longevity: Insights from three independent cohorts. Exp Gerontol 2014; 53: 16-23.
(PMID: 24534555; DOI: 10.1016/j.exger.2014.02.004)

5) Garatachea N, Fuku N, He ZH, Tian Y, Arai Y, Abe Y, Murakami H, Miyachi M, Yvert T, Venturini L, Santiago C, Santos-Lozano A, Rodríguez G, Ricevuti G, Pareja-Galeano H, Sanchis-Gomar F, Emanuele E, Hirose N, Lucia A. PTK2 rs7460 and rs7843014 polymorphisms and exceptional longevity: a functional replication study. Rejuvenation Res 2014; 17(5): 430-438.
(PMID: 24930376; DOI: 10.1089/rej.2014.1570)

6) Okada T, Ikebe K, Inomata C, Takeshita H, Uota M, Mihara Y, Matsuda K, Kitamura M, Murakami S, Gondo Y, Kamide K, Masui Y, Takahashi R, Arai Y, Maeda Y. Association of periodontal status with occlusal force and food acceptability in 70-year-old adults: from SONIC Study. J Oral Rehabil 2014; 41(12): 912-919.
(PMID: 25056986; DOI: 10.1111/joor.12214)

7) Inomata C, Ikebe K, Kagawa R, Okubo H, Sasaki S, Okada T, Takeshita H, Tada S, Matsuda K, Kurushima Y, Kitamura M, Murakami S, Gondo Y, Kamide K, Masui Y, Takahashi R, Arai Y, Maeda Y. Significance of occlusal force for dietary fibre and vitamin intakes in independently living 70-year-old Japanese: from SONIC Study. J Dent 2014; 42(5): 556-564.
(PMID: 24589846; DOI: 10.1016/j.jdent.2014.02.015)

8) Pinós T, Fuku N, Cámara Y, Arai Y, Abe Y, Rodríguez-Romo G, Garatachea N, Santos-Lozano A, Miro-Casas E, Ruiz-Meana M, Otaegui I, Murakami H, Miyachi M, Garcia-Dorado D, Hinohara K, Andreu AL, Kimura A, Hirose N, Lucia A. The rs1333049 polymorphism on locus 9p21.3 and extreme longevity in Spanish and Japanese cohorts. Age (Dordr) 2014; 36(2): 933-943.
(PMID: 24163049; DOI: 10.1007/s11357-013-9593-0)

9) da Rosa G, Martin P, Gondo Y, Hirose N, Ishioka Y, Poon LW; Georgia Centenarian Study. Examination of important life experiences of the oldest-old: cross-cultural comparisons of U.S. and Japanese centenarians. J Cross Cult Gerontol 2014; 29(2): 109-130.
(PMID: 24477838; DOI: 10.1007/s10823-014-9223-z)

2013年以前

1) Gondo Y, Arai Y, Hirose N. Wellbeing in the oldest old and centenarians in Japan. In Wellbeing in later life: Wellbeing: A Complete Reference Guide, volume IV. Ed Kirkwood TBL & Cooper CL. West Sussex, England, John Wiley & Sons, Ltd, 2013.

2) Takayama M, Arai Y, Sasaki S, Hashimoto M, Shimizu K, Abe Y, Hirose N. Association of marine-origin n-3 polyunsaturated fatty acids consumption and functional mobility in the community-dwelling oldest old. J Nutr Health Aging 2013; 17(1): 82-89.

3) Benigni A, Orisio S, Noris M, Iatropoulos P, Castaldi D, Kamide K, Rakugi H, Arai Y, Todeschini M, Ogliari G, Imai E, Gondo Y, Hirose N, Mari D, Remuzzi G.  Variations of the angiotensin II type 1 receptor gene are associated with extreme human longevity. Age (Dordr) 2013; 35(3): 993-1005.
(PMID: 22569962; DOI: 10.1007/s11357-012-9408-8)

4) Sebastiani P, Bae H, Sun FX, Andersen SL, Daw EW, Malovini A, Kojima T, Hirose N, Schupf N, Puca A, Perls TT. Meta-analysis of genetic variants associated with human exceptional longevity. Aging (Albany NY) 2013; 5(9): 653-661. (PMID: 24244950)

5) Robine JM, Herrmann FR, Arai Y, Willcox DC, Gondo Y, Hirose N, Suzuki M, Saito Y. Accuracy of the centenarian numbers in Okinawa and the role of the Okinawan diet on longevity: responses to Le Bourg about the article “Exploring the impact of climate on human longevity”. Exp Gerontol 2013; 48(8): 840-842. (PMID: 23711883; DOI: 10.1016/j.exger.2013.04.015)

6) Robine JM, Herrmann FR, Arai Y, Willcox DC, Gondo Y, Hirose N, Suzuki M, Saito Y. Exploring the impact of climate on human longevity. Exp Gerontol 2012; 47(9): 660-671.
(PMID: 22613089; DOI: 10.1016/j.exger.2012.05.009)

7) Yagi T, Kosakai A, Ito D, Okada Y, Akamatsu W, Nihei Y, Nabetani A, Ishikawa F, Arai Y, Hirose N, Okano H, Suzuki N. Establishment of induced pluripotent stem cells from centenarians for neurodegenerative disease research. PLoS One 2012; 7(7): e41572.
(PMID: 22848530; DOI: 10.1371/journal.pone.0041572)

8) Iinuma T, Arai Y, Fukumoto M, Takayama M, Abe Y, Asakura K, Nishiwaki Y, Takebayashi T, Iwase T, Komiyama K, Gionhaku N, Hirose N. Maximum occlusal force and physical performance in the oldest old: the Tokyo oldest old survey on total health. J Am Geriatr Soc 2012; 60(1): 68-76.
(PMID: 22211666; DOI: 10.1111/j.1532-5415.2011.03780.x)

9) Oguro R, Kamide K, Katsuya T, Akasaka H, Sugimoto K, Congrains A, Arai Y, Hirose N, Saitoh S, Ohishi M, Mira T, Rakugi H. A single nucleotide polymorphism of the adenosine deaminase, RNA-specific gene is associated with the serum triglyceride level, abdominal circumference, and serum adiponectin concentration. Exp Gerontol 2012; 47(2): 183-187. (PMID: 22210125; DOI: 10.1016/j.exger.2011.12.004)

10) Arai Y, Takayama M, Abe Y, Hirose N. Adipokines and aging. J Atheroscler Thromb 2011; 18(7): 545-550.
(PMID: 21551960; DOI: 10.5551/jat.7039)

11) Sumiya C, Arai Y, Takayama M, Abe Y, Hirose N, Asakura K, Nishiwaki Y, Takebayashi T. Vitamin D deficiency and lifestyle factors in the oldest old. J Am Geriatr Soc 2010; 58(11): 2242-2244.
(PMID: 21054317; DOI: 10.1111/j.1532-5415.2010.03122.x)

12) Miura Y, Sato Y, Arai Y, Abe Y, Takayama M, Toda T, Hirose N, Endo T. Proteomic analysis of plasma proteins in Japanese semisuper centenarians. Exp Gerontol 2011; 46(1): 81-85.
(PMID: 20951194; DOI: 10.1016/j.exger.2010.10.002)

13) Arai Y, Iinuma T, Takayama M, Takayama M, Abe Y, Fukuda R, Ando J, Ohta K, Hanabusa H, Asakura K, Nishiwaki Y, Gondo Y, Akiyama H, Komiyama K, Gionhaku N, Hirose N. The Tokyo Oldest Old survey on Total Health (TOOTH): a longitudinal cohort study of multidimensional components of health and well-being. BMC Geriatr 2010; 10: 35. (PMID: 20529368; DOI: 10.1186/1471-2318-10-35)

14) Sebastiani P, Montano M, Puca A, Solovieff N, Kojima T, Wang MC, Melista E, Meltzer M, Fischer SE, Andersen S, Hartley SH, Sedgewick A, Arai Y, Bergman A, Barzilai N, Terry DF, Riva A, Anselmi CV, Malovini A, Kitamoto A, Sawabe M, Arai T, Gondo Y, Steinberg MH, Hirose N, Atzmon G, Ruvkun G, Baldwin CT, Perls TT. RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans. PLoS One 2009; 4(12): e8210.
(PMID: 20011587; DOI: 10.1371/journal.pone.0008210)

15) Arai Y, Kojima T, Takayama M, Hirose N. The metabolic syndrome, IGF-1, and insulin action. Mol Cell Endocrinol 2009; 299(1): 124-128.
(PMID: 18672019; DOI: 10.1016/j.mce.2008.07.002)

16) Inagaki H, Gondo Y, Hirose N, Masui Y, Kitagawa K, Arai Y, Ebihara Y, Yamamura K, Takayama M, Nakazawa S, Shimizu K, Homma A. Cognitive function in Japanese centenarians according to the Mini-Mental State Examination. Dement Geriatr Cogn Disord 2009; 28(1): 6-12.
(PMID: 19602888; DOI: 10.1159/000228713)

17) Shimizu K, Hirose N, Takayama M, Arai Y, Gondo Y, Ebihara Y, Yamamura K, Nakazawa S, Inagaki H, Masui Y, Kitagawa K. Relationship between physical and cognitive function, blood pressure and serum lipid concentration in centenarians. Geriatr Gerontol Int 2008; 8(4): 300-302.
(PMID: 19149843; DOI: 10.1111/j.1447-0594.2008.00479.x)

18) Bilal E, Rabadan R, Alexe G, Fuku N, Ueno H, Nishigaki Y, Fujita Y, Ito M, Arai Y, Hirose N, Ruckenstein A, Bhanot G, Tanaka M. Mitochondrial DNA haplogroup D4a is a marker for extreme longevity in Japan. PLoS One 2008; 3(6): e2421.
(PMID: 18545700; DOI: 10.1371/journal.pone.0002421)

19) Arai Y, Takayama M, Gondo Y, Inagaki H, Yamamura K, Nakazawa S, Kojima T, Ebihara Y, Shimizu K, Masui Y, Kitagawa K, Takebayashi T, Hirose N. Adipose endocrine function, insulin-like growth factor-1 axis, and exceptional survival beyond 100 years of age. J Gerontol A Biol Sci Med Sci 2008; 63(11): 1209-1218.
(PMID: 19038836)

20) Takayama M, Hirose N, Arai Y, Gondo Y, Shimizu K, Ebihara Y, Yamamura K, Nakazawa S, Inagaki H, Masui Y, Kitagawa K. Morbidity of Tokyo-area centenarians and its relationship to functional status. J Gerontol A Biol Sci Med Sci 2007; 62(7): 774-782.
(PMID: 17634326)

21) Gondo Y, Hirose N, Arai Y, Inagaki H, Masui Y, Yamamura K, Shimizu K, Takayama M, Ebihara Y, Nakazawa S, Kitagawa K. Functional status of centenarians in Tokyo, Japan: developing better phenotypes of exceptional longevity. J Gerontol A Biol Sci Med Sci 2006; 61(3): 305-310.

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